I would take a brief look at another remedy which is used in the acute stages of Lyme when first bitten.
Aurum Arsenicum.

This remedy is recommended in Peter Alex’ book as being the genus epidemicus for Lyme. A genus epidemicus remedy is one which is most commonly indicated for an epidemic and has had a positive action in a high number of people.
In this remedy we see the depressive state of Aurum Met and the anxiousness of Arsenicum.
Modalities are better for heat, warmth of bed. Better in Summer. Worse open air. Worse cold, wet weather. Worse for mental and physical exertion.

For more chronic cases a remedy must be individualised and chosen for the client.